This course covers multiple aspects of drug transport, from simple diffusion to protein-mediated active transport of drugs and other xenobiotics. Specific transporters will be discussed in context of clinical and pre-clinical effects on drug disposition. Distribution, substrates, and mechanisms of relevant drug transporters will be discussed, as well as how they can mediate potentially toxic effects of drugs. Students will participate in simulations of real-world scenarios which drug transport can have a clinical impact on drug selection or development
After successful completion of this course students will be able to
- display a deep understanding of active, passive, and diffusion-mediated drug transport,
- exhibit a deep understanding of clinically relevant drug transporters, their mechanisms of action, their substrates, their distribution, and other clinical considerations of said transporters,
- demonstrate a deep understanding of transporter-mediated drug interactions and potential effects of transporter induction or inhibition,
- demonstrate a deep understanding of in vitro assays used to characterize drug transport in preclinical drug development.