Bioinformatics and Data Science

The FAES Academic Programs at NIH offers a unique Advanced Studies in Bioinformatics and Data Science to serve the quickly evolving needs of today’s biomedical research community. As one of the most dynamic fields intersecting biology and computer science, bioinformatics and its data analysis tools equip life sciences researchers and professionals with highly in-demand skills in the pharmaceutical and biotechnology industries. Courses are offered in the evenings, making it convenient for working professionals and postgraduate Fellows to gain expertise and experience in the theoretical foundations and practical skills required to harvest the wealth of information contained in the vast amount of biological phenomena. The courses have been designed to train today’s biomedical researchers in new methods and techniques in data science and prepare them to translate and analyze the immensity of biological data.

General Requirements

The program is designed for participants who hold an advanced degree in life sciences or STEM fields.

The Advanced Studies comprises a 14-credit curriculum required and elective courses. Courses are held in the evenings to fit the needs of working professionals and postgraduate fellows.

Next generation sequencing technologies are producing enormous amount of sequencing data. Analyzing this massive amount of data requires the ability to use the sophisticated tools and techniques.

This workshop introduces participants to bioinformatics tools and methods for analyzing next generation sequencing data, particularly for DNA-seq (Variant analysis), RNA-seq (Transcriptome analysis), ChIP-seq (Transcriptional factor binding analysis), and network-based integration of NGS data.

This workshop introduces advanced RNA-Seq analysis techniques and tools for detecting snps, fusion genes, allele specific expressions, circular RNAs, viral/bacterial sequence identification, alternative polyadenylation, and transcriptional regulatory network analysis.

Metagenomics is gaining importance due to low-cost next generation sequencing technologies. This workshop introduces end-to-end solutions for analyzing metagenomic data, including data-quality analysis, alignment, community profiling, taxonomic comparison, and novel taxa discovery.

R is the industry standard for creating specific graphs and plots. This workshop walks participants through creating interactive, static, and shareable plots using popular R packages. The workshop will cover formatting data, loading data, setting parameters, creating images, and saving outputs.

Predicting the effect of a mutation on the structure and function of a protein is not just for researchers with computer facilities.  Users with basic molecular biology background can set up and run intensive computational modeling and dynamics experiments.  In this workshop, participants will use open-source tools and techniques to conduct molecular modeling and dynamics experiments.

Next generation sequencing technologies have made genotyping a day to day research and diagnostic tool. Genotyping has come all the way from bench-to-bedside. Genetic variants are being used in personalized medicine to identify susceptibility genes, common disease variants and mutations relevant for diagnosis and therapy.

This workshop will cover the use of popular open-source tools and techniques necessary for analyzing variants starting from raw data-quality control. In addition to alignment, variant calling, and annotation, this workshop will walk participants through several advanced variant analysis methods and techniques.

Bioinformatics (Computational Biology) is a must skill required in every modern biomedical research lab. Installing and configuring a wide variety of computational biology tools is a cumbersome task that requires software engineering skills.

This workshop provides an introduction to basic concepts in using popular tools and techniques for sequence analysis, structure analysis, function prediction, biological database searching, “omics” data analysis, pathway analysis, data visualization, data curation and integration, and scripting basics.

In order for a drug to get approved by the FDA for market in the USA, the sponsor must ultimately demonstrate the drug has: 1) a predictable exposure profile with dose; 2) a good safety profile; and 3) is effective at safe doses. Therefore, the pharmacology of a drug is essentially being reviewed by the FDA. The ability of scientists to analyze drug exposure/response relationships is crucial to understanding what exposure amount will elicit the safest, most effective response, and ultimately what dose amount and frequency will produce the optimal exposure amount. Additionally, the ability to identify sub-populations that may produce differing exposure or response levels is key to providing as many subjects as possible a safe and effective dose. This quantitative exposure/response analyses, often referred to pharmacometrics, is key to making go/no go decisions both during clinical trials by investigators and by the FDA during the subsequent review period. Participants will learn basic pharmacology theory with introductory statistics using a popular open-source software program (R Studio) that is capable of conducting pharmacokinetic (PK) exposure and pharmacodynamic (PD) response analyses from example clinical trial data. Ultimately, the framework of analyzing exposure/response relationships will be demonstrated in order to make go/no go decisions. This course is designed for researchers and clinicians interested in learning how to utilize freely available software to explore, visualize, and understand drug exposure/response relationships where responses include any clinical endpoint collected on a trial, or for researchers and clinicians interested in understanding and predicting the effect of different doses on drug exposure as well as the effect of exposure on a variety of clinically relevant response endpoints (biomarkers), or for medical, pharmacy, dental, nursing, and lab-based graduate-school students interesting in obtaining a deeper understanding of pharmacokinetics, exposure/response analyses, as well as a broad understanding of clinical drug development and the impact of pharmacometrics on decisions.

Scientists generate more data than ever before. It can be daunting to determine how to extract insights from a mountain of data. Data science is a relatively new discipline that combines traditional statistics and analytics with programming to produce novel insights, intelligently automated processes, and data-driven decisions.

This course will equip you with everything you need to complete a basic data science project using Python from beginning to end. Participants will be exposed to a practical, real-world use case, which will be built on throughout the course. Students will use the data from this use case to perform exploratory analysis and build their skills up to advanced analytics.

Computer programs are meant to perform repeated, monotonous, fast, reproducible tasks, handling any amount of data. Researchers often come across situations where existing programs don't suit their needs. In the era of BigData, without the ability to quickly put together a program that would solve their problem, researchers face a road block that is not efficiently solvable by a human. This training will walk through participants in writing programs that would help them solve their own problems.

Members of the QIIME development group will lead this hands-on workshop on bioinformatics tools for microbial ecology. The workshop will include lectures covering basic QIIME usage and theory, and hands-on work with QIIME, to perform microbiome analysis from raw sequence data through publication-quality statistics and visualizations. The workshop will also cover related bioinformatics tools including DADA2,Emperor, scikit-bio, and an introduction to applied bioinformatics. This workshop will provide the foundation on which participants can begin using these tools to advance their own studies of microbiome analysis or microbial ecology. This is a hands-on workshop. Participants must bring their laptop. This workshop will be on QIIME2 platform only.

MATLAB® is a programming platform designed for scientists and engineers. This course provides a comprehensive introduction to the MATLAB® technical computing environment. No prior programming experience or knowledge of MATLAB is assumed. Themes of data analysis, visualization, modeling, and programming are explored throughout the course.

This course provides hands-on experience with performing image analysis. Examples and exercises demonstrate the use of appropriate MATLAB® and Image Processing Toolbox™ functionality throughout the analysis process. The course also provides hands-on experience with performing computer vision tasks. Examples and exercises demonstrate the use of appropriate MATLAB® and Computer Vision System Toolbox™ functionality.

Rosetta is a set of tools used for protein structure prediction and designing. Rosetta is capable of predicting structures either with or without prior knowledge. Apart from large and small molecular docking, Rosetta is also popular for designing novel proteins and peptides.

The course will go over the capabilities of Rosetta, followed by hands-on walk-through for predicting protein structures, docking and protein designing.

As big data becomes the norm and experiments continue to increase in scale, proper understanding and use of statistics is becoming increasingly important for scientists in every field. While experimental researchers are expert in concepts related to their respective fields and receive extensive scientific education, statistical training is relatively lacking. As a result, experimental researchers may feel overwhelmed or uncertain about how to correctly use statistics to quantify their experimental results and how to properly interpret the results of those statistical tests. Unfortunately, this knowledge gap can result in both reduced understanding of reported results in scientific publications as well as superficial or potentially inaccurate reported statistics. This course serves as a practical, hands-on workshop to close the knowledge gap and help experimental researchers learn how to choose a statistical test for their data, how to perform those tests, and how to interpret the results. The workshop starts by establishing a solid foundation in basic statistical theory before advancing to practical applications of statistical tests on real data.

R is a popular platform to perform statistical analysis. This workshop introduces how to perform basic statistical analysis using the R platform. First, participants will learn to use the R and RStudio software platforms. Followed by an introduction to basic statistical concepts, participants will do hands-on exercises to perform basic statistical analysis using the R platform.

Python is a free, open-source and powerful programming language that is easy to learn. This course is intended for non- programmers who want to learn how to write programs that expand the breadth and depth of their daily research. Most elementary concepts in modern software engineering will be covered, including basic syntax, reading from and writing texts files, debugging python programs, regular expressions, and creating reusable code modules that are distributable to peers. The course will also focus on potential applications of Python to bioinformatics, including sequence analysis, data visualization and data analysis. Students will also learn to use the Jupyter Notebook and the PyCharm integrated development environment (IDE), which are available at no cost.

INDIVIDUAL LAPTOP IS NEEDED FOR EACH CLASS.
Continuum Analytics Installer Anaconda (V3) will be utilized to install Python and the necessary packages.

Python is a free, open-source and powerful programming language that is easy to learn. This course is intended for non-programmers who want to learn how to write programs that expand the breadth and depth of their daily research. Most elementary concepts in modern software engineering will be covered, including basic syntax, reading from and writing texts files, debugging python programs, regular expressions, and creating reusable code modules that are distributable to peers. The course will also focus on potential applications of Python to bioinformatics, including sequence analysis, data visualization and data analysis. Students will also learn to use the Jupyter Notebook and the PyCharm integrated development environment (IDE), which are available at no cost. INDIVIDUAL LAPTOP IS NEEDED FOR EACH CLASS. Continuum Analytics Installer Anaconda (V3) will be utilized to install Python and the necessary packages.

The goal of this course is to introduce biomedical research scientists to R as an analysis platform rather than a programming language. Throughout the course, emphasis will be placed on example-driven learning. Topics to be covered include: installation of R and R packages; command line R; R data types; loading data in R; manipulating data; exploring data through visualization; statistical tests; correcting for multiple comparisons; building models; and, generating publication-quality graphics. No prior programming experience is required.

INDIVIDUAL LAPTOP IS NEEDED FOR EACH CLASS.

The goal of this course is to introduce biomedical research scientists to R as an analysis platform rather than a programming language. Throughout the course, emphasis will be placed on example-driven learning. Topics to be covered include: installation of R and R packages; command line R; R data types; loading data in R; manipulating data; exploring data through visualization; statistical tests; correcting for multiple comparisons; building models; and, generating publication-quality graphics. No prior programming experience is required. INDIVIDUAL LAPTOP IS NEEDED FOR EACH CLASS.

Between Electronic Medical Records and Electronic Health Records, PubMed, and collections of biomedical grant applications, there exist large quantities of medical information stored in databases waiting to be explored. Besides tables of numbers, medical records also contain a great amount of free-text paragraphs that are comprehensible to human readers but challenging to computers. Text mining is an interdisciplinary area that primarily combines advances in Natural LanguageProcessing (NLP), Information Retrieval (IR), and Machine Learning (ML) to help the computers understand human written language and thus extract medical and clinical information from free-text records. This class aims to introduce fundamental subjects in text mining such as tokenization, named entity recognition (NER), grammars, parsing, relation extraction, and document classification. The class is oriented towards hands-on experience with Python and Natural Language Toolkit (NLTK).

Between Electronic Medical Records and Electronic Health Records, PubMed, and collections of biomedical grant applications, there exist large quantities of medical information stored in databases waiting to be explored. Besides tables of numbers, medical records also contain a great amount of free-text paragraphs that are comprehensible to human readers but challenging to computers. Text mining is an interdisciplinary area that primarily combines advances in Natural Language Processing (NLP), Information Retrieval (IR), and Machine Learning (ML) to help the computers understand human written language and thus extract medical and clinical information from free-text records. This class aims to introduce fundamental subjects in text mining such as tokenization, named entity recognition (NER), grammars, parsing, relation extraction, and document classification. The class is oriented towards hands-on experience with Python and Natural Language Toolkit (NLTK).

In this course, students will learn how to apply Convolutional Neural Networks (CNNs) to MRI scans to perform a variety of medical tasks and calculations. Upon completion of this course, students will be able to apply CNNs to MRI scans to conduct a variety of medical tasks. INDIVIDUAL LAPTOP IS NEEDED FOR EACH CLASS (Mac, Linux or Windows).

This course will demonstrate and practice the use of R in creating and presenting data visualizations. After a short introduction to R tools, especially the tidy verse packages, the course will cover principles for data visualization, examples of good and bad visualizations, and the use of ggplot2 to create static publication-quality graphs. Students will also have the chance to learn about modern web-based interactive graphics using the html widgets packages as well as dynamic graphics and dashboards that can be created using flex dashboard and Shiny. The course will explore ways in which bioinformatics data can be presented using static and dynamic visualizations. Finally, RMarkdown and other packages will be used to develop webpages for presenting data visualizations as self-explanatory and possibly interactive storyboards.

Enormously large series of complex and chaotic events have shaped the genomes of eukaryotes, prokaryotes, and viruses.This course will address cutting-edge approaches to the computational investigation of these events, with an eye toward developments in translational systems biology. The course will begin by presenting the fundamentals of evolutionary genomics, including basic properties of genomes and comparative genomics, population genetics, and sequence-structure-function relationships. Experimental design and biological project integration will be a major theme of the course. Specific lectures on statistical analysis, similarity searches, Next Generation Sequencing, epigenomics, and other specialized topics will supplement those given in the earlier part of the course.

What is Data Science, and how can one use Big Data technologies to unlock value in massive data stores? How can one explore scientific data to gain new insights or make better data-management decisions? The objective of this course is to provide an overview of the history of Data Science platforms and its current landscape in order to enable students to implement their own Data Science solution, while also providing hands-on experience with these tools. The course will cover the basics of some tools that students can subsequently use to work with Data Science, such as Hadoop’s MapReduce,Apache Spark, Pig, Hive, Python, and R. In addition, the course will cover advanced data structures as well as real-world data scraping, cleansing, and wrangling. The course will also include a high-level overview of machine-learning concepts. INDIVIDUAL LAPTOP IS NEEDED FOR EACH CLASS (Mac, Linux or Windows).

R is a free statistics software that is becoming increasingly popular and important for data analysis in biology. During the course, students will first learn how to handle the R programming environment. Next, students will learn how to simulate data for analysis, while the background for R programming will be provided in accompanying lectures. At the end of the course, students will become familiar with simple R programming, which they will be then able to apply for their own data analysis.

Machine learning is a computational field that consists of techniques allowing computers to learn from data and make data-driven predictions or decisions. The ability to implement machine learning approaches appropriately and intelligently is a crucial component of data analysis. BIOF 509 provides a broad practical introduction to machine learning concepts, analysis design, and implementation. The course will give a broad and conceptual overview of the most popular machine learning algorithms, followed by examples of how and when to apply them to real data. Best practices in designing machine learning analyses will be emphasized and reviewed, along with how to avoid common pitfalls and how to interpret analysis results. Through homework and in-class assignments, students will implement machine-learning models in Python, utilizing state-of-the-art machine learning Python packages, such as scikit-learn and tensor flow. Algorithms that will be covered include, but are not limited to linear and logistic regression, random forest, K-means clustering, and deep learning. Note that the course emphasizes hands-on application of algorithms, and mathematical derivation will not be reviewed. Further, depending on the students’ familiarity with Python, completing the weekly homework assignments can take one to four hours. The course will culminate in a short research project utilizing machine learning to analyze either the student’s own dataset or a public dataset that the student chooses. INDIVIDUAL LAPTOP IS NEEDED FOR EACH CLASS. Photo by Markus Spiske temporausch.com from Pexels

The objective of this course is to give students an introduction into the theory and practice of a wide range of bioinformatic techniques and applications, enabling them to use these tools in their own research. This course will be divided into five modules: statistical approaches in sequence analysis; phylogenetic analysis of nucleotide and protein sequences; acquisition and analysis of sequence datasets, including EST and RNA-seq data; analysis of genomic datasets from an evolutionary perspective; and, prediction of protein secondary structure. Two or three of the five sessions in each module will be divided roughly 60 percent theoretical lecture and 40 percent learning to use relevant computational tools. The final session of each module will be split between a discussion of computational tools, a journal club, and a discussion of work on a project assigned for each module. By the end of the course, students should be able to acquire many types of sequence data, identify orthologous and paralogous genes, predict domains and motifs, identify alternative splicing, analyze genomic/protein alignments, and make a prediction of secondary protein structure from primary sequence.

The objective of this course is to give students an introduction into the theory and practice of a wide range of bioinformatic techniques and applications, enabling them to use these tools in their own research. This course will be divided into five modules: statistical approaches in sequence analysis; phylogenetic analysis of nucleotide and protein sequences; acquisition and analysis of sequence datasets, including EST and RNA-seq data; analysis of genomic datasets from an evolutionary perspective; and, prediction of protein secondary structure. Two or three of the five sessions in each module will be divided roughly 60 percent theoretical lecture and 40 percent learning to use relevant computational tools. The final session of each module will be split between a discussion of computational tools, a journal club, and a discussion of work on a project assigned for each module. By the end of the course, students should be able to acquire many types of sequence data, identify orthologous and paralogous genes, predict domains and motifs, identify alternative splicing, analyze genomic/protein alignments, and make a prediction of secondary protein structure from primary sequence.

In this course, students will learn to analyze Next Generation Sequencing data particularly for DNA-seq, RNA-seq, CHIP-seq, and DNA-methylation. The course will be divided between lectures and hands-on sessions. Lectures will cover background knowledge and a survey of various software programs. For hands-on sessions, the course will primarily focus on the use of the Galaxy platform for analysis of raw data obtained from an Illumina’s HiSeq-2000 and data available in the NCBI-SRA. Use of distributed and abstracted computing, such as Biowulf and cloud computing, will be also covered. There will be a term project in which students will design projects relevant to their research. INDIVIDUAL LAPTOP IS NEEDED FOR EACH CLASS.

This is a first course in calculus and is aimed at students of diverse backgrounds who have previously not taken any formal course on the subject. The course includes a brief review of pre-calculus topics, including functions and algebra, and then moves on to computations using infinity and beyond: infinitesimal quantities, differentials, infinite sequences, and whether it is possible to divide by zero. Scientific applications and achievements will motivate the exploration of the essential single-variable calculus concepts of limits, derivatives, and integrals.

This is the first part of a two-part course. Registration is required separately for each part of the course.

This is a first course in calculus and is aimed at students of diverse backgrounds who have previously not taken any formal course on the subject. The course includes a brief review of pre-calculus topics, including functions and algebra, and then moves on to computations using infinity and beyond: infinitesimal quantities, differentials, infinite sequences, and whether it is possible to divide by zero. Scientific applications and achievements will motivate the exploration of the essential single-variable calculus concepts of limits, derivatives, and integrals.

This is the second part of a two-part course. The completion of the first part (MATH 127) is required before taking the second part. Registration is required separately for each part of the course.

This course is a continuation of MATH 127 and is focused on multivariable and vector calculus. It covers calculus of curves in space, vector functions, functions of more than one variable, and introduces vector calculus. Applications of this more general descriptions of calculus to scientific research will also be presented.

This is the first part of a two-part course. Registration is required separately for each part of the course.

This course is a continuation of MATH 127 and is focused on multivariable and vector calculus. It covers calculus of curves in space, vector functions, functions of more than one variable, and introduces vector calculus. Applications of this more general descriptions of calculus to scientific research will also be presented.

This is the second part of a two-part course. The completion of the first part (MATH 129) is required before taking the second part. Registration is required separately for each part of the course.

This is a first course in linear algebra, aimed at students with diverse backgrounds. It covers the content of a standard textbook: linear systems, vectors and matrices, dimensions and bases of vector spaces, eigenvalues and eigenvectors, singular value decomposition. It is also dedicated to explain applications of these linear algebra concepts in classic analysis methods as well as state-of-the-art statistical inference and machine learning approaches -- in this applications portion of the course we will strive to tailor the content to the interests and research needs of the students.

This is the first part of a two-part course. Registration is required separately for each part of the course.

This is a first course in linear algebra, aimed at students with diverse backgrounds. It covers the content of a standard textbook: linear systems, vectors and matrices, dimensions and bases of vector spaces, eigenvalues and eigenvectors, singular value decomposition. It is also dedicated to explain applications of these linear algebra concepts in classic analysis methods as well as state-of-the-art statistical inference and machine learning approaches -- in this applications portion of the course we will strive to tailor the content to the interests and research needs of the students.

This is the second part of a two-part course. The completion of the first part (MATH 215) is required before taking the second part. Registration is required separately for each part of the course.

This course introduces statistical concepts and essential techniques that are frequently used in biomedical data analysis. The emphasis will be equally divided between solid understanding of basic principles and their applications. R software is introduced and used for demonstration throughout the course. Topics covered in the second semester: test of statistical hypothesis; one- and two-sample tests; power and sample size calculation; analysis of variance (ANOVA); nonparametric tests; linear regression; analysis of categorical data; permutation and bootstrap; data analysis using R.

This is the first part of a two-part course. Registration is required separately for each part of the course.

This course introduces statistical concepts and essential techniques that are frequently used in biomedical data analysis. The emphasis will be equally divided between solid understanding of basic principles and their applications. R software is introduced and used for demonstration throughout the course. Topics covered in the second semester: test of statistical hypothesis; one- and two-sample tests; power and sample size calculation; analysis of variance (ANOVA); nonparametric tests; linear regression; analysis of categorical data; permutation and bootstrap; data analysis using R.

This is the second part of a two-part course. The completion of the first part (prerequisite) is required before taking the second part. Registration is required separately for each part of the course.

This course introduces statistical concepts and essential techniques that are frequently used in biomedical data analysis. The emphasis will be equally divided between solid understanding of basic principles and their applications. R software is introduced and used for demonstration throughout the course. Topics covered in the second semester: test of statistical hypothesis; one- and two-sample tests; power and sample size calculation; analysis of variance (ANOVA); nonparametric tests; linear regression; analysis of categorical data; permutation and bootstrap; data analysis using R.

This is the first part of a two-part course. Registration is required separately for each part of the course.

This course introduces statistical concepts and essential techniques that are frequently used in biomedical data analysis. The emphasis will be equally divided between solid understanding of basic principles and their applications. R software is introduced and used for demonstration throughout the course. Topics covered in the second semester: test of statistical hypothesis; one- and two-sample tests; power and sample size calculation; analysis of variance (ANOVA); nonparametric tests; linear regression; analysis of categorical data; permutation and bootstrap; data analysis using R.

This is the second part of a two-part course. The completion of the first part (STAT 203) is required before taking the second part. Registration is required separately for each part of the course.

The objective of this course is to learn the concepts and methodology used in the design and conduct of randomized clinical trials. Topics to be covered will include the description of main types of trial designs, principles of randomization and stratification, issues in protocol development (defining objectives and endpoints, blinding, choice of control), recruitment and retention, data collection and quality control issues, monitoring, and analyses of trials reports. Textbook material will be frequently supplemented by material from the literature. Guest lecturers will give lectures on power and sample size calculations, life table analysis, quality of life and cost evaluation. Examples from the cardiovascular, pulmonary, and cancer areas will be used when appropriate. The course is intended for biomedical researchers desiring exposure to the clinical-trial field. In order to run this course, minimum 10 students need to register.

The objective of this course is to provide a deeper understanding of epidemiologic research methodology that can be used to interpret critically the results of epidemiologic research. This understanding will result from investigating conceptual models for study designs, disease frequency, measures of association and impact, imprecision, bias, and effect modification. The course will emphasize the interpretation of research, even when the design or execution of the respective research is less than ideal.

The course will cover the fundamentals of the SAS program and its variables, creating data, importing data (from text and Excel files), exporting data (to text, pdf, and Microsoft-related formats), manipulating data, and providing descriptive statistics. Students will have the opportunity to practice in class, using sample datasets. Homework and project assignments will be provided as well.

The course will cover advanced SAS coding concepts such as the use of SAS Macro, SAS SQL, as well as a combination of both. The course will also introduce students to SAS STAT coding for common statistical tests (such as t-test, ANOVA, linear regression, and others). Students will have the opportunity to practice in class, using sample datasets. Homework and project assignments will be provided as well.

The objective of this course is to provide an overview of statistics for biomedical researchers and clinicians who are interested in the interpretation of the results of statistical analyses. This is a series of integrated lectures, readings, and exercises on analysis and interpretation of medical research data using Excel. Emphasis is on ideas and understanding rather than mechanics. Topics covered include the foundation of statistical logic, interpretation of the most commonly encountered statistical procedures in medical research, and selection of an appropriate method to analyze a particular set of data. The second semester expands on the material covered in the first semester.

This is the first part of a two-part course. Registration is required separately for each part of the course.

The objective of this course is to provide an overview of statistics for biomedical researchers and clinicians who are interested in the interpretation of the results of statistical analyses. This is a series of integrated lectures, readings, and exercises on analysis and interpretation of medical research data using Excel. Emphasis is on ideas and understanding rather than mechanics. Topics covered include the foundation of statistical logic, interpretation of the most commonly encountered statistical procedures in medical research, and selection of an appropriate method to analyze a particular set of data. The second semester expands on the material covered in the first semester.

This is the second part of a two-part course. The completion of the first part (STAT 500) is required before taking the second part. Registration is required separately for each part of the course.

The objective of this course is to provide an overview of statistics for biomedical researchers and clinicians who are interested in the interpretation of the results of statistical analyses. This is a series of integrated lectures, readings, and exercises on analysis and interpretation of medical research data using Excel. Emphasis is on ideas and understanding rather than mechanics. Topics covered include the foundation of statistical logic, interpretation of the most commonly encountered statistical procedures in medical research, and selection of an appropriate method to analyze a particular set of data. Those who will be routinely engaged in computing statistical procedures should consider STAT 200.

This is the first part of a two-part course. Registration is required separately for each part of the course.

The objective of this course is to provide an overview of statistics for biomedical researchers and clinicians who are interested in the interpretation of the results of statistical analyses. This is a series of integrated lectures, readings, and exercises on analysis and interpretation of medical research data using Excel. Emphasis is on ideas and understanding rather than mechanics. Topics covered include the foundation of statistical logic, interpretation of the most commonly encountered statistical procedures in medical research, and selection of an appropriate method to analyze a particular set of data. Those who will be routinely engaged in computing statistical procedures should consider STAT 200.

This is the second part of a two-part course. The completion of the first part (STAT 502) is required before taking the second part. Registration is required separately for each part of the course.