BIOL 003
Methods in Molecular Biology
This lecture and hands-on laboratory course is designed to provide participants with an introduction to molecular biology and recombinant DNA technology, along with related laboratory procedures that are widely used in biotechnology. Participants in this workshop will acquire skills in the use of generic methods, and through an understanding of such methods, will improve their effectiveness as staff in a contemporary research laboratory. Participants will learn about nucleic acids, strategies for cloning that includes various types of PCRs, and analysis of cloned products.
Credits
-BIOL 007A
Basic Techniques in Mammalian Cell Culture
This three-day lecture and laboratory course is structured to provide life scientists who are not experienced in mammalian cell culture with an introduction to the principles and practices that will facilitate their ability to develop the use of in vitro systems. After successful completion of the workshop, participants are expected to feel comfortable handling general mammalian cell lines, detecting most common problems in cell culture room and troubleshoot accordingly.
Credits
-BIOL 039
Epigenetics
Credits
-BIOL 042
Bio-Techniques
Bio-techniques, a three-week credit bearing training course, consists of online and hands-on laboratory components. The course examines the fundamental concepts underlying biomedical science as well as principles and methods of scientific techniques commonly used in molecular biology labs. Additionally, during the 5-day lab sessions, students will practice some of these techniques and learn when and how to apply these techniques when designing their own experiments.
Online: Basic concepts of molecular and cell biology; Principles and methods of experimental techniques used in a molecular biology laboratory
Laboratory: general lab safety, pipetting, microscope, mammalian cell culture, molecular cloning, bacterial transformation, nucleic acids and protein isolation, polymerase chain reaction, transfection, SDS-PAGE and Western blotting, bioinformatics tools
The goals of the course are to describe the characteristics of the major cellular macromolecules; explain the structure and function of major cellular components; build and hone critical thinking skills; gain a working knowledge of practical scientific techniques commonly used in a molecular biology research lab; and Brainstorm experimental design and best practices for technique applications
Students will earn 4 graduate credits through the FAES Academic Programs after successful completion of the course.
Credits
4BIOL 055
Genome Editing with CRISPR
This course will focus on the general principles of genome editing protocols, including design, choice of format, delivery, efficiency, specificity, clonal isolation, genotyping, and validation. The second part of the course will address different applications including genome editing in mice, zebrafish, and iPS cells, disease modeling, generation of reporter lines, and high throughput approaches. We will discuss strategies to make CRISPR gene editing more efficient, flexible, and specific. We will explore recent advances in the CRISPR field including base editors and epigenome editing. We will also examine sequencing and quality control considerations for genome editing projects. Hands-on laboratory exercises will accompany the lecture material to provide practical training in design, assembly, transfection, and detection/evaluation steps of a typical genome editing workflow.
Credits
-BIOL 092
Nucleic Acid (DNA or RNA) Library Preparation for Next Generation Sequencing (NGS)
This hands-on lab training will prepare DNA, RNA, or single cell RNA libraries for Illumina Next Generation Sequencing under the instruction of experts from the industry using commercially available kits. This workshop also provides an opportunity for participants to bring their project-specific samples.
Credits
-BIOL 101
Foundations in Biomedical Science I
This course examines the fundamental concepts underlying biomedical science, including the structure and function of biomolecules, such as proteins, enzymes, carbohydrates, lipids, and DNA, as well as the structure and function of cellular components, such as membranes, vesicles, organelles, and the cytoskeleton. This course is designed for students who may have previously studied biology but need a refresher on the main concepts in biomedical science as well as students without a science background who wish to gain a foundation in basic biological mechanisms.
Credits
2Learning Objectives:
- Describe the characteristics of the major cellular macromolecules Explain the structure and function of major cellular components Build and hone critical thinking skills
Sample syllabus is subject to change.
BIOL 102
Foundations in Biomedical Science II
This course continues the exploration of the fundamental concepts underlying biomedical science, including DNA replication, transcription, translation, signal transduction mechanisms, apoptosis, the cell cycle, and cancer. This course is designed for students who may have previously studied biology but need a refresher on the main concepts in biomedical science as well| as students without a science background who wish to gain a foundation in basic biological mechanisms and is a continuation of Foundations in Biomedical Science I.
Credits
2Prerequisites
The above course(s) or permission from the instructor.
Learning Objectives:
- Trace the flow of genetic information at the intracellular level, from DNA to protein Summarize the cell cycle and will analyze examples of cell cycle dysfunction Build and hone critical-thinking skills
Sample syllabus is subject to change.
BIOL 222
Genomics in Modern Society
The human genome is the DNA book of life, containing information to create networks of proteins that construct a human being. The course discusses how the genome was read, how variants in DNA information are detected, and how this information changes views of disease, medical treatments, and our image of ourselves as a species. Through an historical perspective, students will discover the role of DNA, RNA, and proteins as the molecules of life and explore some of the most current applications of molecular biology and biochemistry to biomedical research, forensic analyses, and molecular anthropology. Students will be provided with the basic scientific foundations necessary to understand the vast impact of biotechnology on modern society. The class format will combine lectures with case-studies discussions, presentations, and screenings of media. Students are required to actively search media and scientific sources to find recent breaking news pertinent to the field. Each week will feature a critical discussion based on a specific topic.
Credits
2Learning Objectives:
- Place life sciences into a historical perspective and describe current developments
- Describe the role of DNA, RNA, and proteins as the chemical foundations of life
- Summarize and explain some of the key aspects of biotechnology, such as DNA sequencing, cloning and amplification through PCR, the biological production of drugs and the –omics world (genomics, transcriptomics, proteomics, metabolomics)
- Critically examine the application of DNA-based analyses to the study of human evolution (molecular anthropology) and forensic science
BIOL 254
Non-Coding RNAs (miRNAs, lncRNAs, and circRNAs) and Exosomes: Biology and Diseases
This course will address the biology, function, and expression of non-coding RNAs, including microRNAs, long noncoding RNA, and circular RNAs. It will address exosomes in the light of these non-coding RNAs. The course will also highlight the involvement of non-coding RNAs and exosomes in human diseases as well as the potential treatment with RNA therapeutics. The objective of this course is to provide an overview of cutting-edge scientific knowledge to researchers who need to understand this fast-emerging field and who plan to investigate non-coding and exosomes. Classes will cover different aspects of non-coding RNAs and exosomes from the perspectives of molecular biology, their role in diseases and RNA therapeutic implications as well as reference databases for data mining. By the end of the course, students should be able to discuss basic science, the disease biology of non-coding RNAs and exosomes; students should also gain knowledge of technology approaches suitable for their research projects.
Credits
1Learning Objectives:
- Learn the basics and latest scientific findings in the field of non-coding RNAs, such as microRNAs, long noncoding RNA, and circular RNAs, and exosomes
- 1. MicroRNAs biogenesis and functions
- 2. Long non-coding RNAs biology and functions
- 3. Exosomes, microRNAs, and non-coding RNAs
- 4. Non-coding RNAs and Exosomes in Disease Biology » Microbiome » Immune responses » Stem cells
BIOL 262
Research Tools for Studying Diseases I
This course is designed to help students gain an appreciation of essential scientific approaches and techniques in studying various human diseases and biological disorders. A variety of techniques are discussed, including molecular, cellular, biochemical, genetic, imaging, computational, and high-throughput screening approaches. Students will learn applications and recent advances for each approach as well as gain a historical perspective on the development of each technique. Emphasis will be placed on the appropriate application of each technique, with a focus on the exploration of the progression and therapeutic effects of treatments to various diseases. The course provides individuals of all backgrounds and levels of experience with the opportunity to become knowledgeable in a wide variety of scientific approaches in biomedical research.
Credits
1Prerequisites
Solid knowledge of undergraduate biology and chemistry.
Learning Objectives:
- Introduce various approaches to biomedical and translational research
- Provide fundamental knowledge of various scientific techniques essential for conducting research
- Develop critical-thinking and problem-solving abilities and learn about practical applications of research techniques covered in this course
- Learn about various diseases and how research leads to better therapeutic applications
Sample syllabus is subject to change.
BIOL 263
Research Tools for Studying Diseases II
This course is the continuation of Research Tools for Studying Diseases I and is designed to help students gain an appreciation of essential scientific approaches and techniques in studying various human diseases and biological disorders. A variety of techniques are discussed, including molecular, cellular, biochemical, genetic, imaging, computational, and high-throughput screening approaches. Students will learn applications and recent advances for each approach as well as gain a historical perspective on the development of each technique. Emphasis will be placed on the appropriate application of each technique, with a focus on the exploration of the progression and therapeutic effects of treatments to various diseases. The course provides individuals of all backgrounds and levels of experience with the opportunity to become knowledgeable in a wide variety of scientific approaches in biomedical research.
Credits
1Prerequisites
The above course(s) or permission from the instructor.
Learning Objectives:
- Introduce various approaches to biomedical and translational research
- Provide fundamental knowledge of various scientific techniques essential for conducting research
- Develop critical-thinking and problem-solving abilities and learn about practical applications of research techniques covered in this course
- Learn about various diseases and how research leads to better therapeutic applications
BIOL 313
Molecular Biology and Recombinant DNA Technology
Credits
2Learning Objectives:
- Gain basic molecular biology knowledge of how genetic material (DNA and RNA) is the key to our survival and function and how this information is transferred over generations
- Understand how changes in this basic information encoded by the genetic material lead to changes in biological characteristics
- Master and use the most advanced tools and experimental techniques to study cell and molecular biology
- Describe how recombinant DNA techniques are used in modern applications in the lab or industry to develop cures for diseases and biotechnological advancements that affect daily life
BIOL 325
Human Neuroscience I
This course will use a systems neuroscience approach to understanding the relationship between the structure and function of the human brain. Course material will span the level of cellular neurophysiology of neurons and synaptic signaling to circuits and brain regions involved in sensory processes, motor function, emotion, attention, and learning and memory. Neuroanatomy will be emphasized throughout the course. Deviation from normative structure and function will be considered through clinical case studies and translational research. Although the focus of this course will be the human brain, research from animal models, particularly non-human primates and rodents, will be included in the investigation of neuronal mechanisms.
Credits
2Prerequisites
Prior introductory biology coursework is encouraged; supplemental materials will be available for students who have not had a prior introduction to biophysical properties of cell membranes and cell signaling processes.
Learning Objectives:
- Identify neuroanatomical landmarks of the human brain in schematic illustrations, magnetic resonance images, and micrographs of sections of post-mortem tissue
- Analyze clinical cases and evaluate which neural regions are likely to be involved in symptoms and injury
- Describe basic neurophysiological properties and be able to explain: how the properties of the neuronal membrane relate to changes in potential and salutatory conduction of action potentials; the evidence for quantal transmission of chemical signals at the synapse; and the effects of various neurotoxins on receptor-binding kinetics or neurotransmission
- Apply knowledge of receptive fields, neuronal ‘tuning,’ neuronal codes, and topographic maps to compare and contrast the structural and functional properties of the somatosensory, motor, and sensory systems
- Think critically about scientific investigations by participating in an online discussion of scientific papers, giving careful consideration to potential confounds, alternative explanations, significance of findings, and unanswered questions for future inquiry
BIOL 326
Human Neuroscience II
This course will use a systems neuroscience approach to understanding the relationship between the structure and function of the human brain. Course material will span the level of cellular neurophysiology of neurons and synaptic signaling to circuits and brain regions involved in sensory processes, motor function, emotion, attention, and learning and memory. Neuroanatomy will be emphasized throughout the course. Deviation from normative structure and function will be considered through clinical case studies and translational research. Although the focus of this course will be the human brain, research from animal models, particularly non-human primates and rodents, will be included in the investigation of neuronal mechanisms.
Credits
2Prerequisites
Prior introductory biology coursework is encouraged; supplemental materials will be available for students who have not had a prior introduction to biophysical properties of cell membranes and cell signaling processes.
Learning Objectives:
- Identify neuroanatomical landmarks of the human brain in schematic illustrations, magnetic resonance images, and micrographs of sections of post-mortem tissue
- Analyze clinical cases and evaluate which neural regions are likely to be involved in symptoms and injury
- Describe basic neurophysiological properties and be able to explain: how the properties of the neuronal membrane relate to changes in potential and salutatory conduction of action potentials; the evidence for quantal transmission of chemical signals at the synapse; and the effects of various neurotoxins on receptor-binding kinetics or neurotransmission
- Apply knowledge of receptive fields, neuronal ‘tuning,’ neuronal codes, and topographic maps to compare and contrast the structural and functional properties of the somatosensory, motor, and sensory systems
- Think critically about scientific investigations by participating in an online discussion of scientific papers, giving careful consideration to potential confounds, alternative explanations, significance of findings, and unanswered questions for future inquiry
BIOL 327
Modern Embryonic and Developmental Biology
This course covers the molecular mechanisms that regulate vertebrate embryonic development. Discussions range from conserved evolutionary processes to defects and genetic mutations in human development and disease. Specific topics include: cell-cell interactions; organogenesis; brain, cardiovascular and limb development; stem cell generation, maintenance and migration; cloning and genetic manipulations; epigenetic modification and system biology. Each class will include discussions of current literature, with emphasis on processes and mechanisms of development. This course is suitable for students preparing to pursue careers in research, medicine, and/or health, Fellows studying mouse models with developmental defects, and those wishing to expand their understanding of growth and development of complex organisms. Students will have opportunities to read, evaluate, and discuss critically research articles.
Credits
2Prerequisites
The above course(s), understanding of college level biology, or permission from the instructor.
Learning Objectives:
- Expand on knowledge of elementary cell biology to include development of complex organisms and genetic origin of human disease
- Acquire understanding of developmental processes and resulting impact of genetic mutations
- Advance scientific communication skills toward critical evaluation of scientific literature
BIOL 350
Foundations of Cellular Neuroscience I
This course explores a wide range of cellular neuroscience, including: membrane biophysics and action potentials; ion channels; synaptic transmission and plasticity; dendritic integration and computation. Lectures also introduce techniques used to record and image activity and signaling in neurons as well as quantitative methods used to analyze experimental data. The course also features in-depth discussions of classic and current literature, with problem sets and exams to enhance and test the understanding of lecture materials.
Credits
2Learning Objectives:
- Develop conceptual and quantitative understanding of basic cellular physiology and biophysics
- Learn about electrophysiological and imaging techniques used in neuroscience experiments
- Gain a historical perspective on the study of ion channels, synapses and neurons
BIOL 351
Foundations of Cellular Neuroscience II
This course explores a wide range of cellular neuroscience, including: membrane biophysics and action potentials; ion channels; synaptic transmission and plasticity; dendritic integration and computation. Lectures also introduce techniques used to record and image activity and signaling in neurons as well as quantitative methods used to analyze experimental data. The course also features in-depth discussions of classic and current literature, with problem sets and exams to enhance and test the understanding of lecture materials.
Credits
2Learning Objectives:
- Develop conceptual and quantitative understanding of basic cellular physiology and biophysics
- Learn about electrophysiological and imaging techniques used in neuroscience experiments
- Gain a historical perspective on the study of ion channels, synapses and neurons
BIOL 356
Connective Tissue Biology
Credits
2Prerequisites
college-level cell biology and biochemistry.
Learning Objectives:
- Master basic structure and function of connective tissues and how they relate to other organs
- Appreciate the role of connective tissues in diseases
- Discuss properties of biomaterials required for regenerative medicine applications
BIOL 385
The Biology of Aging
Credits
2Prerequisites
cell biology.
Learning Objectives:
- Describe the evolutionary theories that explain aging
- Outline the cellular pathways that influence the aging phenotype
- Understand factors that influence the aging process
- Gain fluency with reading and interpreting primary literature
BIOL 425
RNA Interference and CRISPR
RNA interference (RNAi) is the process of inhibition of gene expression by RNA molecules. The mechanism for RNAi in prokaryotes and eukaryotes was evolutionarily developed as defense against pathogen invasion. CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats is a similar defensive mechanism found in certain bacteria. Detailed understanding of their molecular mechanism enabled adaptation of these as tools for down regulating specific gene expression in mammalian cells. This course is designed to provide a deeper understanding of RNA interference and CRISPR and their applications in different fields of biology.
Credits
1Prerequisites
Basic understanding of molecular biology and cell biology.
Learning Objectives:
- Understand the mechanism of RNA interference and CRISPR
- Learn different types of RNA interferences and study of gene function using RNAi
- Learn challenges in RNAi and CRISPR applications and adaptation to high throughput screens
- Learn computational approaches of high throughput RNAi/CRISPR screen data analysis
- Review of therapeutic applications of RNAi/CRISPR
BIOL 427
Advances and Applications in Developmental Biology
Advances and Applications in Developmental Biology will employ current and cutting-edge medical and research publications to explore the principles of developmental biology. Together we will discuss how these publications are rooted in lessons from developmental biology but apply those lessons at a high level to medically relevant research. Each week we will include a lesson on the historical context and advances in developmental biology that have led us to the current point. We will then discuss the significance of current research, its place in the field, and what contributions it makes to developmental biology as well as medical science as a whole.
Credits
2Prerequisites
Learning Objectives:
- Connect concepts in papers with classical developmental biology principles.
- Evaluate hypotheses and experimental design of research groups based on principles of developmental biology
- Analyze choice of model organism/system for the goal of each study
- Debate the implications of the study for advancement of health science research
- Design alternative or entirely novel experiments/studies to test ideas
BIOL 435
Current Trends in the Neurobiology of Mental Illness
The objective of this graduate-level course is to provide an overview of the biological basis of major neuropsychiatric disorders as well as to explore the emerging methodologies (both basic sciences and clinical) utilized in the study of these brain disorders. A group of leading scientists and clinicians has been recruited to provide lectures in their areas of expertise. Disorders to be covered include: bipolar disorder; major depression; anxiety disorders; schizophrenia; autism; and, substance dependence. Speakers will discuss the evidence supporting current theories related to each disorder, with particular emphasis on the limitations of current diagnostic systems and methodologies, the prospects for the greatest advances, and their individual contributions to the field. Additionally, specific lectures will focus on methodologies that are rapidly having a major impact on neuroscience research as well as advancing our understanding of neural function, disease mechanisms, diagnostic systems, biomarkers, and drug discovery and development. Areas to be discussed will include: positron imaging tomography; magnetic resonance imaging (functional and structural); animal models; biochemical techniques; genetic and epidemiological analysis; and, statistical modeling. Students enrolled in the course will be expected to develop an understanding of the advanced techniques used to study these illnesses and pathways to develop new treatments.
Credits
2Prerequisites
familiarity with college-level neurobiology, biochemistry, and genetics.
Learning Objectives:
- Demonstrate a familiarity with recent and groundbreaking novel research regarding the biological basis of major neuropsychiatric disorders
- Develop a broad knowledge of the scope and impact of mental illness through the synthesis of recent advances in etiology and treatment of pathophysiology
- Identify and describe the methodologies impacting neuroscience research, including positron emission tomography, magnetic resonance imaging, animal models, and genetics
- Discover real-world applications of material into future research, medical or graduate study pursuits
- Complete a final short-answer examination which incorporates material from all topics and guest speakers
BIOL 440
Medical and Veterinary Entomology
Designed for entomology, biology, veterinary, and medical students, this course is an introduction to the natural history of the major groups of the Phylum Arthropoda that directly or indirectly impact the health of humans, pets, and livestock. Classes will cover the life- cycles of arthropods and parasites, clinical signs and symptoms of disease, disease epidemiology, and approaches to control of arthropod-borne diseases with an emphasis on vector control. Recent advances in the field of medical/veterinary entomology research and case studies will be discussed. Guest lecturers will share their expertise with the students.
Credits
2BIOL 450
Stem Cell Biology
Credits
1Learning Objectives:
- Learn the origin and residence of stem cells in embryos and adult tissues
- Discuss the basis for self-renewal and pluripotency of stem cells, the regulation of stem cells in embryogenesis and their differentiation into adult tissues
- Survey the role of stem cells in human disease, with focus on cancer
- Consider the pros and cons of induced pluripotent stem cells in tissue regeneration and therapeutics
- Discover normal and cancer stem cell niche and fate determination
GENE 220
Evolutionary Genetics and Genomics: From Charles Darwin to Integrated-Omics
Credits
2Prerequisites
undergraduate-level genetics.
Learning Objectives:
- Explain key paradigms, advancements, and scientists contributing to evolutionary genetics and evolutionary theory, starting with early nineteenth-century scientific thought
- Analyze experimental strategies and key studies of evolutionary genetics, focusing on specific examples of advancements in understanding hereditary disorders and genetic conditions
- Discuss early paradigms of selective breeding and hereditary, the “Modern Synthesis,” discoveries of chromosomal inheritance as well as the central dogma of molecular biology
- Discuss basic gene regulation paradigms, developmental genetics and evolutionary-developmental biology, and conceptualization of genetics in the ‘-omics era’
- Review and report on a specific historical example of evolutionary genetics of own interest or relevance
GENE 500
Introduction to Medical Genetics I
The objective of this two-semester course is to provide an introduction to clinical and human genetics for Fellows and genetic counseling students who are preparing for subspecialty examinations of the American Board of Medical Genetics and for others who wish to learn about the expanding role of genetics in medicine. The first semester will introduce basic concepts of genetics, cytogenetics, and molecular genetics. The second semester will include presentations on clinical topics emphasizing the diagnosis and management of patients with genetic disorders. This course is designed for Fellows and genetic counseling students who are preparing for subspecialty examinations of the American Board of Medical Genetics and others who wish to learn about the expanding role of genetics in medicine.
This is the first part of a two-part course. Registration is required separately for each part of the course.Credits
1Prerequisites
Graduate-level training or experience in the biomedical sciences or consent of the course instructor.
Learning Objectives:
- Fall:
- Appreciate organization of the human genome and tools used to investigate it
- Acquire skills to determine the most likely mode of inheritance of a trait, to interpret the results of linkage and association studies
- Spring:
- Appreciate the impact genetic disorders have on the various organ systems
- Acquire skills to develop a differential diagnosis and appropriate work-up for a given phenotype
GENE 501
Introduction to Medical Genetics II
The objective of this two-semester course is to provide an introduction to clinical and human genetics for Fellows and genetic counseling students who are preparing for subspecialty examinations of the American Board of Medical Genetics and for others who wish to learn about the expanding role of genetics in medicine. The first semester will introduce basic concepts of genetics, cytogenetics, and molecular genetics. The second semester will include presentations on clinical topics emphasizing the diagnosis and management of patients with genetic disorders. This course is designed for Fellows and genetic counseling students who are preparing for subspecialty examinations of the American Board of Medical Genetics and others who wish to learn about the expanding role of genetics in medicine.
This is the second part of a two-part course. The completion of the first part (prerequisite) is required before taking the second part. Registration is required separately for each part of the course.
Credits
1Prerequisites
The above course(s) or permission from the instructor. Graduate-level training or experience in the biomedical sciences or consent of the course instructor.
Learning Objectives:
- Fall:
- Appreciate organization of the human genome and tools used to investigate it
- Acquire skills to determine the most likely mode of inheritance of a trait, to interpret the results of linkage and association studies
- Spring:
- Appreciate the impact genetic disorders have on the various organ systems
- Acquire skills to develop a differential diagnosis and appropriate work-up for a given phenotype
GENE 505
Embryology, Developmental Biology, and Human Malformations
Credits
1Prerequisites
permission of the course instructor.
Learning Objectives:
- Connect conceptually the apparently distinct disciplines of embryology, developmental biology, and clinical medicine to appreciate mechanisms of normal and abnormal development
- Appreciate the role of evolution for understanding the mechanistic basis of malformations and as a basis for the study of these disorders in animal models
- Develop skills of integrating data from clinical, anatomic and molecular studies to form a comprehensive description of malformations
GENE 510
Genetic Counseling: Professional Topics Seminar Part I
The objective of this course is to address the psychological, clinical, social, and ethical issues in genetic counseling (GC). This class offers a dynamic forum for discussion, focusing on genetics counseling research, policy and education, and their impact on clinical practice. A diverse group of professionals present topics well suited for class discussions. Student-led case presentations and discussions highlight pertinent psychological, social, and ethical issues in genetic counseling. Clients who have had personal experiences with a genetic condition or risk expose students to a variety of attitudes, reactions, and experiences. Students enrolled in related graduate programs are encouraged to enroll to maximize the opportunity for exchange among disciplines. This course presents an opportunity to college graduates interested in genetic counseling to learn about the theoretical and practical aspects of the profession.
This is a required course for graduate students enrolled in the JHU/NHGRI Genetic Counseling Training Program. Tuition: $500 per credit.
Credits
1Prerequisites
Permission of the instructors.
Learning Objectives:
- Participate in dynamic discussions of provocative issues in the field of GC, with faculty input
- Facilitate appreciation for pursuing GC as a profession both for professional and pertinent issues in clinical work
- Foster ideas and model projects in GC research
- Learn directly from clients about their personal experiences with genetic conditions
- Promote interaction among graduate students to facilitate mentoring, strategizing, and camaraderie
GENE 511
Genetic Counseling: Professional Topics Seminar Part II
The objective of this course is to address the psychological, clinical, social, and ethical issues in genetic counseling (GC). This class offers a dynamic forum for discussion, focusing on genetics counseling research, policy and education, and their impact on clinical practice. A diverse group of professionals present topics well suited for class discussions. Student-led case presentations and discussions highlight pertinent psychological, social, and ethical issues in genetic counseling. Clients who have had personal experiences with a genetic condition or risk expose students to a variety of attitudes, reactions, and experiences. Students enrolled in related graduate programs are encouraged to enroll to maximize the opportunity for exchange among disciplines. This course presents an opportunity to college graduates interested in genetic counseling to learn about the theoretical and practical aspects of the profession.
This is the second part of a two-part course. The completion of the first part (prerequisite) is required before taking the second part. Registration is required separately for each part of the course.
This is a required course for graduate students enrolled in the JHU/NHGRI Genetic Counseling Training Program. Tuition: $500 per credit.
Credits
1Prerequisites
The above course(s) or permission from the instructor.
Learning Objectives:
- Participate in dynamic discussions of provocative issues in the field of GC, with faculty input
- Facilitate appreciation for pursuing GC as a profession both for professional and pertinent issues in clinical work
- Foster ideas and model projects in GC research
- Learn directly from clients about their personal experiences with genetic conditions
- Promote interaction among graduate students to facilitate mentoring, strategizing, and camaraderie
GENE 514
Current Concepts in Clinical Molecular Genetics and Molecular Diagnostics
Credits
1Prerequisites
GENE 500 and permission of the instructor.
Learning Objectives:
- Appreciate the types of techniques used in molecular genetic diagnostic laboratories, including the limitations of each assay
- Acquire skills in calculating residual risks after molecular testing
GENE 518
Medical Genetics and Genomic Medicine: From Diagnosis to Treatment I
The objective of this course is to discuss how advances in genetics have impacted genetic disorders, from their diagnosis to treatment, by building upon the foundations learned in GENE 500. Topics include Smith-Lemli-Opitz syndrome, Rasopathies, neurocutaneous syndromes, muscular dystrophies, cohesinopathies, connective tissue disorders, ciliopathies, and psychosocial and genetic counseling issues in the era of genomic medicine. The course is designed as part of the required curriculum for residents, Fellows, and students preparing for the Genetics Certification Boards given by the American Board of Medical Genetics and the American Board of Genetic Counseling.
This is the first part of a two-part course. Registration is required separately for each part of the course.
Credits
1Prerequisites
The above course(s) or permission from the instructor.
Learning Objectives:
- Appreciate how advances in genetics have impacted genetic disorders, from their diagnosis to treatment
- Acquire skills to conduct a dysmorphology examination
GENE 519
Medical Genetics and Genomic Medicine: From Diagnosis to Treatment II
The objective of this course is to discuss how advances in genetics have impacted genetic disorders, from their diagnosis to treatment, by building upon the foundations learned in GENE 500. Topics include Smith-Lemli-Opitz syndrome, Rasopathies, neurocutaneous syndromes, muscular dystrophies, cohesinopathies, connective tissue disorders, ciliopathies, and psychosocial and genetic counseling issues in the era of genomic medicine. The course is designed as part of the required curriculum for residents, Fellows, and students preparing for the Genetics Certification Boards given by the American Board of Medical Genetics and the American Board of Genetic Counseling.
This is the second part of a two-part course. The completion of the first part (prerequisite) is required before taking the second part. Registration is required separately for each part of the course.
Credits
1Prerequisites
The above course(s) or permission from the instructor.
Learning Objectives:
- Appreciate how advances in genetics have impacted genetic disorders, from their diagnosis to treatment
- Acquire skills to conduct a dysmorphology examination
GENE 644
Review of Medical Genetics
Tuition: $1000.00.
The objective of this course is to provide a review for candidates for the American Board of Medical Genetics Subspecialty examinations: clinical genetics; molecular genetics; biochemical genetics; cytogenetics; and, genetic counseling. Topics to be covered include statistical and mathematical subjects in clinical genetics and population genetics, clinical cytogenetics, dysmorphology, ophthalmologic genetics, and general treatment and management of genetic diseases.
Credits
2Prerequisites
nBoard candidate for any subspecialty exam of the American Board of Medical Genetics.
Learning Objectives:
- Review the fundamentals of genetics and a variety of genetic disorders in preparation for the American Board of Medical Genetics certification examination
- Acquire skills to recognize and eliminate distractors on the certification exam
MEDI 234
Precision Medicine
Credits
1Learning Objectives:
- Assess how The Human Genome Project has advanced technology in biomedical research
- Translate research and technology into the delivery of healthcare and basic science research findings to the benefit of the general public
- Discuss implications in privacy and policy laws for precision medicine in the age of the Affordable Care Act and the All of Us Research Program
- Present coherent case studies encompassing previous objectives, including caveats in the use of current technologies
MEDI 275
Fundamental Principles of Histology
This course examines the morphology of different cell types and their arrangement within tissues using both light microscopy and electron microscopy images. The course will begin with a detailed overview of the basic tissues: epithelial; connective; muscle; and, nervous tissues. The four basic tissues will then be applied to organ systems, and a discussion of some clinical pathologies will follow. The course will also cover cell functions within the different tissues as well as tissue preparations and types of stains to highlight different characteristics of tissue.
Credits
2Prerequisites
Knowledge of biology and/or cell biology.
Learning Objectives:
- Define and describe histological characteristics of different cell types
- Identify different tissue types and organization within organs
- Understand functions of cell types within the tissue
- Gain general knowledge of tissue preparation and commonly used staining techniques
- Understand how the different cell types and basic tissues come together to function as a whole organ
MEDI 303
Physiological Mechanisms of Acupuncture
Credits
1Prerequisites
basic medical knowledge.
Learning Objectives:
- Understand the basic theories of TCM, including acupuncture
- Explore the mechanisms of TCM therapies from the perspective of modern science
MEDI 309
Introduction to Molecular Medicine
Credits
2Prerequisites
college-level knowledge of biology and/or chemistry.
Learning Objectives:
- Identify interactions between metabolic pathways and human diseases
- Describe recent advances in medical applications of biotechnology and genetics
- Discuss health issues in relation to molecular mechanisms of the cell
- Prepare an original presentation about a disease of interest to the class
MEDI 311
Principles of Endocrinology
Credits
2Prerequisites
general biology and chemistry required; prior coursework in introductory biochemistry and human physiology
recommended.
Learning Objectives:
- Identify and describe the key hormones and their roles in metabolism, digestion, reproduction, and growth
- Understand regulation of hormonal control, including the principles of feedback control and hormone-receptor interactions
- Problem solve the biological basis of endocrine disorders and treatments
- Develop the scientific background needed to understand the literature about endocrine function and pathology
MEDI 317
Human Physiology I
Credits
2Prerequisites
general biology; BIOL 101 or equivalent.
Learning Objectives:
- Understand structure-function relationships of the systems of the human body
- Identify the structural and functional levels of organization from cellular to organ system levels
- Describe how the body adapts to different everyday situations and environmental stresses
- Explain the principle of homeostasis and feedback-control mechanisms as they relate to body systems
- Develop active learning styles through problem solving in physiology
- Apply knowledge of functional mechanisms and their regulation to explain the pathophysiology underlying common disorders
- Communicate physiologic concepts to a variety of audiences
MEDI 318
Human Physiology II
Credits
2Prerequisites
general biology; BIOL 101 or equivalent; MEDI 317 Human Physiology I or equivalent.
Learning Objectives:
- Understand structure-function relationships of the systems of the human body
- Identify the structural and functional levels of organization from cellular to organ system levels
- Describe how the body adapts to different everyday situations and environmental stresses
- Explain the principle of homeostasis and feedback-control mechanisms as they relate to the body systems
- Develop active learning styles through problem solving in physiology
- Apply knowledge of functional mechanisms and their regulation to explain the pathophysiology underlying common disorders
- Communicate physiologic concepts to a variety of audiences
MEDI 335
Current Topics in Omics Research for Metabolic Syndrome, IBD, and Gastrointestinal Cancers
This course provides a comprehensive survey of the pathophysiology of digestive and metabolic diseases and disorders, focusing on the most common diseases with public health implications. Diseases include, but are not limited to inflammatory bowel diseases (IBDs), diabetes and metabolic syndrome, common microbial infections, liver disease, irritable bowel syndrome (IBS), and GI cancers. Diagnoses, symptomology, and treatment strategies will be presented by guest lecturers with clinical and research expertise in specific disease pathologies. Within the context of these clinical topics on GI and metabolic disease, the underlying physiological, molecular, and cellular mechanisms will be reviewed and discussed along with current research. The course will be comprised of a combination of lectures and discussions, with reading assignments, an exam, a writing assignment, and a group presentation assignment.
Credits
1Prerequisites
Undergraduate coursework in cell biology, genetics, physiology, or college degree in biomedical sciences.
Learning Objectives:
- Identify the most common gastrointestinal/metabolic diseases
- Explain diagnostic criteria and symptoms associated with each disease/disorder; describe treatment strategies for each disorder
- Describe and discuss the underlying physiological, cellular, and molecular mechanisms associated with each disease
- Demonstrate an understanding of the relationship between pathology and the underlying physiological, molecular, and cellular mechanisms for each disease
- Analyze and critique research publications and data investigating the pathophysiological mechanisms for a selected disease
MEDI 339
Introduction to Cancer Biology
This course will cover the genetic basis of cancer, initiation and progression of cancer, signal transduction, tumor microenvironment, and metastasis. Additional topics will include cancer genomics, epithelial to mesenchymal transition, adhesion, angiogenesis, targeted therapies, and animal models. This course will also have a journal-club component, which will enable students to read and discuss scientific journal articles related to the course.
Credits
2Learning Objectives:
- Identify cancer biology terms and apply terms and information in textbook to case studies
- Discuss and present a scientific paper in detail, such as background information, experimental design, and findings
MEDI 345
Human Anatomy I
Human anatomy will be taught using a systemic approach and emphasizing the connection between function and structure as it relates to physiological conditions and diseases. To this end, lectures will integrate elements of embryology and histology. Modern imaging methods will be introduced as well. Selected topics of topographic anatomy will be also examined, including head/neck and pelvis. A mid-term and final exam will be offered to allow students to assess their comprehension of the material. This course is suitable for advanced undergraduate and/or postbac students planning a career in medicine and biomedical research and will be taught at a level of complexity that is similar to courses offered at most medical schools. Other biomedical researchers who seek to better understand the structural underpinnings of normal and pathologic functions of the human body may also find the course useful.
Credits
2Prerequisites
College degree; basic knowledge of cell biology.
Learning Objectives:
- Master principles of human anatomy using a systemic approach
- Revise fundamentals of embryology and general micro-anatomy (histology)
- Learn macro-anatomy, including musculo-skeletal, nervous, cardiovascular, respiratory, digestive, urogenital, and endocrine systems
- Acquire ability to understand how anatomical systems interact, and how structural and functional characteristics of tissues, organs, and systems are intimately interdependent
- Describe topographic anatomy of selected regions
MEDI 346
Human Anatomy II
Human anatomy will be taught using a systemic approach and emphasizing the connection between function and structure as it relates to physiological conditions and diseases. To this end, lectures will integrate elements of embryology and histology. Modern imaging methods will be introduced as well. Selected topics of topographic anatomy will be also examined, including head/neck and pelvis. A mid-term and final exam will be offered to allow students to assess their comprehension of the material. This course is suitable for advanced undergraduate and/or postbac students planning a career in medicine and biomedical research and will be taught at a level of complexity that is similar to courses offered at most medical schools. Other biomedical researchers who seek to better understand the structural underpinnings of normal and pathologic functions of the human body may also find the course useful.
Credits
2Prerequisites
College degree; basic knowledge of cell biology.
Learning Objectives:
- Master principles of human anatomy using a systemic approach
- Revise fundamentals of embryology and general micro-anatomy (histology)
- Learn macro-anatomy, including musculo-skeletal, nervous, cardiovascular, respiratory, digestive, urogenital, and endocrine systems
- Acquire ability to understand how anatomical systems interact, and how structural and functional characteristics of tissues, organs, and systems are intimately interdependent
- Describe topographic anatomy of selected regions
MEDI 501
Principles of Preclinical Translational Science
Translation is the process of turning observations in the laboratory, clinic and community into interventions that improve the health of individuals and the public — from diagnostics and therapeutics to medical procedures and behavioral changes.
Translational Science is an emerging field that seeks to identify broadly generalizable scientific and operational principles for translational research. Translational science examines translational research from a systems perspective to develop approaches that can improve the efficiency and effectiveness of translational research endeavors, broadly.
In this course, students will learn key principles of translational science, taught by way of a case study of a highly successful translational research partnership involving the National Center for Advancing Translational Sciences (NCATS), the National Cancer Institute (NCI), Northwestern University and the University of Kansas. The partnership produced a promising potential drug shown to inhibit metastasis in animal models, which is being examined in a first-in-human clinical trial in 2020.
Credits
1Learning Objectives:
- Understand the definitions and goals of translational research and translational science and how they differ.
- Identify a range of scientific and operational principles that can be applied to enhance preclinical translational research projects.
- Learn about the research process necessary to enable a scientific discovery to produce an effective compound that can be used in humans.
- Learn about the varied roles of different disciplines, as well as agencies — including industry, government agencies, and academic faculty and institutions — in advancing translational research and how to facilitate effective interagency and team-based partnerships.
Sample syllabus is subject to change.
MEDI 507
Inborn Errors of Metabolism
The objective of this course is to provide an overview of the principles and practice of human biochemical genetics. Topics to be covered include amino acidopathies, organic acidoses, disorders of carbohydrate metabolism and lipid metabolism, lysosomal storage diseases, peroxisomal diseases, purine and pyrimidine disorders, and a variety of other inborn errors of metabolism. Students will research a topic and present the lectures. Several quizzes are planned, and student participation will be strongly encouraged.
Credits
3Prerequisites
graduate degree; this is an advanced course, largely geared toward Ph.D.s and M.D.s.
Learning Objectives:
- Recognize the signs and symptoms of biochemical disorders of man
- Understand the principles of diagnosing and treating inborn errors of metabolism based upon knowledge of human biochemical pathways
- Prepare for managing patients with biochemical disorders and for taking the American Board of Medical Genetics examination in biochemical genetics.